Announcement PDF Form 604 Corporations Act 2001 Section 671B Notice of Change of Interests of Substantial Holder To: STARPHARMA HOLDINGS LIMITED ACN/ARSN: 1. Details of substantial holder (1) Name: FIL Limited and the entities listed in Annexure A ("FIL") ACN/ARSN (if applicable) There was a change in the interests of the substantial holder on The previous notice was given to the company on The previous notice was dated 18 September 2023 17 August 2023 17 August 2023 2. Previous and present voting power The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate (2) had a relevant interest (3) in when last required, and when now required, to give a substantial holding notice to the company or scheme, are as follows: Class of Securities (4) COMMON STOCK Previous Notice Previous Notice Person’s votes Voting Power (5) 25,777,420 6.28% Present Notice Person’s votes 21,422,025 Present Notice Voting Power (5) 5.22% 3. Changes in relevant interests Particulars of each change in, or change in the nature of, a relevant interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows: Date of Change 08/16/2023 08/16/2023 08/17/2023 08/17/2023 08/17/2023 08/17/2023 08/17/2023 08/17/2023 08/17/2023 08/17/2023 08/17/2023 Person whose relevant interest changed FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL Nature of change (6) SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL Consideration given in relation to change (7) 0.1634 AUD 0.1634 AUD 0.1618 AUD 0.1618 AUD 0.1618 AUD 0.1618 AUD 0.1618 AUD 0.1618 AUD 0.1618 AUD 0.1618 AUD 0.1618 AUD Class and number of securities affected COMMON STOCK 72,217 47,117 47,561 47,561 275,424 47,561 47,561 47,561 47,561 128,344 47,561 Person’s votes affected COMMON STOCK 72,217 47,117 47,561 47,561 275,424 47,561 47,561 47,561 47,561 128,344 47,561 08/18/2023 08/21/2023 08/22/2023 08/23/2023 09/04/2023 09/04/2023 09/04/2023 09/04/2023 09/04/2023 09/05/2023 09/08/2023 09/08/2023 09/08/2023 09/08/2023 09/08/2023 09/11/2023 09/12/2023 09/15/2023 09/15/2023 09/15/2023 09/15/2023 09/15/2023 09/18/2023 09/18/2023 09/18/2023 09/18/2023 09/18/2023 FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL 0.1605 AUD 0.1611 AUD 0.1600 AUD 0.1650 AUD 0.1500 AUD 0.1500 AUD 0.1500 AUD 0.1500 AUD 0.1500 AUD 0.1500 AUD 0.1584 AUD 0.1584 AUD 0.1584 AUD 0.1584 AUD 0.1584 AUD 0.1550 AUD 0.1550 AUD 0.1695 AUD 0.1695 AUD 0.1695 AUD 0.1695 AUD 0.1695 AUD 0.1518 AUD 0.1518 AUD 0.1518 AUD 0.1518 AUD 0.1518 AUD 84,709 82,342 43,465 556 51,334 51,334 51,334 76,157 276,218 5,016 49,457 49,457 49,457 49,457 98,341 75,918 8,316 45,969 65,586 162,013 326,140 1,206,499 51,270 51,270 51,270 92,881 343,600 84,709 82,342 43,465 556 51,334 51,334 51,334 76,157 276,218 5,016 49,457 49,457 49,457 49,457 98,341 75,918 8,316 45,969 65,586 162,013 326,140 1,206,499 51,270 51,270 51,270 92,881 343,600 4. Present Relevant Interest Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows: Refer to Annexure A 5. Changes in Association The persons who have become associates (2) of, ceased to be associates of, or have changed the nature of their association (9) with, the substantial holder in relation to voting interests in the company or scheme are as follows: Name and ACN/ARSN (if applicable) N/A Nature of association 6. Addresses The addresses of persons named in this form are as follows: Refer to Annexure A Sign Here ____________________________________ Dated: 20 September 2023 Patrick Cheung Head of Regulatory Reporting, Asia Pacific Duly authorized under Powers of Attorney by and on behalf of FIL Limited Annexure A Investment Manager Address Custodian FIL Investment Management (Australia) Limited Level 11, 167 Macquarie Street, Sydney, NSW 2000, Australia Level 21, Two Pacific Place, 88 Queensway, Admiralty, Hong Kong NATIONAL AUSTRALIAN BANK NORTHERN TRUST LONDON (C) FIL Investment Management (Hong Kong) Limited Grand Total STATE STREET LUXEMBOURG BROWN BROS HARRIMN LTD LUX (C) CLEARSTREAM BANKING SA LUX (C) LANDESBANK BADEN-WUERTTEMBERG Nature of Relevant Interest Investment Discretion / Voting Power Sum of Numerator Shares 475,433 3,820,210 897,916 11,958,950 2,060,329 2,209,187 21,422,025