Announcement PDF Form 605 Corporations Act 2001 Section 671B Notice of Ceasing to be a Substantial Holder To: STARPHARMA HOLDINGS LIMITED ACN/ARSN: 1. Details of substantial holder (1) Name: FIL Limited and the entities listed in Annexure A ("FIL") ACN/ARSN (if applicable) The holder ceased to be a substantial holder on The previous notice was given to the company on The previous notice was dated 27 September 2023 20 September 2023 20 September 2023 2. Changes in relevant interests Particulars of each change in, or change in the nature of, a relevant interest (2) of the substantial holder or an associate (3)in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows: Date of Change 09/19/2023 09/20/2023 09/20/2023 09/20/2023 09/20/2023 09/20/2023 09/21/2023 09/21/2023 09/21/2023 09/21/2023 09/22/2023 09/25/2023 09/26/2023 09/27/2023 09/27/2023 09/27/2023 09/27/2023 Person whose relevant interest changed FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL Nature of change (4) SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL SELL Consideration given in relation to change (5) Class (6) and number of securities affected 0.1500 AUD 0.1575 AUD 0.1575 AUD 0.1575 AUD 0.1575 AUD 0.1575 AUD 0.1658 AUD 0.1658 AUD 0.1658 AUD 0.1658 AUD 0.1650 AUD 0.1554 AUD 0.1511 AUD 0.1556 AUD 0.1556 AUD 0.1556 AUD 0.1556 AUD Total Sells COMMON STOCK 29,180 49,292 53,569 49,292 198,167 49,292 54,586 46,641 46,810 46,810 14,889 24,040 74,821 49,816 62,242 247,665 33,468 (1,130,580) Person’s votes affected COMMON STOCK 29,180 49,292 53,569 49,292 198,167 49,292 54,586 46,641 46,810 46,810 14,889 24,040 74,821 49,816 62,242 247,665 33,468 (1,130,580) 3. Changes in Association The persons who have become associates (2) of, ceased to be associates of, or have changed the nature of their association (7) with, the substantial holder in relation to voting interests in the company or scheme are as follows: Name and ACN/ARSN (if applicable) N/A Nature of association 4. Addresses The addresses of persons named in this form are as follows: Refer to Annexure A Sign Here ____________________________________ Dated: 29 September 2023 Patrick Cheung Head of Regulatory Reporting, Asia Pacific Duly authorized under Powers of Attorney by and on behalf of FIL Limited Annexure A Investment Manager Address Custodian FIL Investment Management (Australia) Limited Level 11, 167 Macquarie Street, Sydney, NSW 2000, Australia Level 21, Two Pacific Place, 88 Queensway, Admiralty, Hong Kong NORTHERN TRUST LONDON (C) STATE STREET LUXEMBOURG BROWN BROS HARRIMN LTD LUX (C) CLEARSTREAM BANKING SA LUX (C) LANDESBANK BADEN-WUERTTEMBER G FIL Investment Management (Hong Kong) Limited Grand Total Nature of Relevant Interest Sum of Numerator Shares 3,496,462 566,517 Investment Discretion / Voting Power 11,958,950 2,060,329 2,209,187 20,291,445