Announcement PDF Form 604 Corporations Act 2001 Section 671B Notice of Change of Interests of Substantial Holder To: Starpharma Holdings Ltd ACN/ARSN: 1. Details of substantial holder (s) Name: FIL Limited and the entities listed in Annexure A (“FIL”) ACN/ARSN (if applicable) There was a change in the interests of the substantial holder on The previous notice was given to the company on The previous notice was dated 10 December 2015 30 June 2015 30 June 2015 2. Previous and present voting power The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate (2) had a relevant interest (3) in when last required, and when now required, to give a substantial holding notice to the company or scheme, are as follows: Class of Securities (4) Common Stock Previous Previous Notice Present Notice Present Notice Notice Voting Power (5) Person’s votes Voting Power (5) Person’s votes 19,654,406 6.16% 25,675,108 8.01% 3. Changes in relevant interests Particulars of each change in, or change in the nature of, a relevant interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows: Date of Change Person whose relevant interest changed Nature of change (6) Consideration given in relation to change (7) AUD$ 6/29/2015 6/30/2015 7/10/2015 7/14/2015 7/15/2015 7/16/2015 8/5/2015 8/12/2015 FIL FIL FIL FIL FIL FIL FIL FIL BUY BUY BUY BUY BUY BUY BUY BUY 0.70 0.70 0.69 0.69 0.70 0.69 0.69 0.66 Class and number of securities affected Person’s votes affected Common Stock 143,475 26,872 50,950 220,000 202,936 399,203 48,353 29,166 Common Stock 143,475 26,872 50,950 220,000 202,936 399,203 48,353 29,166 8/14/2015 9/3/2015 9/28/2015 11/16/2015 11/20/2015 11/20/2015 11/20/2015 11/23/2015 11/23/2015 11/23/2015 11/24/2015 12/10/2015 12/10/2015 12/10/2015 12/10/2015 12/10/2015 12/10/2015 FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL FIL BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY BUY 0.67 0.61 0.72 0.90 0.85 0.85 0.85 0.86 0.86 0.86 0.85 0.73 0.73 0.73 0.73 0.73 0.73 Total Buy 26,759 12,294 18,462 29,189 95 8,219 67,075 11,143 173,309 393,245 24,635 63,716 20,442 3,730,579 126,740 107,247 86,598 6,020,702 26,759 12,294 18,462 29,189 95 8,219 67,075 11,143 173,309 393,245 24,635 63,716 20,442 3,730,579 126,740 107,247 86,598 6,020,702 4. Present Relevant Interest Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows: Refer to Annexure A 5. Changes in Association The persons who have become associates (2) of, ceased to be associates of, or have changed the nature of their association (9) with, the substantial holder in relation to voting interests in the company or scheme are as follows: NA 6. Addresses The addresses of persons named in this form are as follows: Refer to Annexure A Sign Here: _______________________________ Dated: 14 December 2015 Kelvin Lo Head of Regulatory Reporting, Asia Pacific Duly authorized under Powers of Attorney on behalf of FIL Limited Annexure A Investment Manager Address Custodian FIL INVESTMENT MANAGEMENT (AUSTRALIA) LIMITED Level 11, 167 Macquarie Street, Sydney, NSW 2000 FIL INVESTMENT MANAGEMENT (HONG KONG) LIMITED Suite 2201, Level 22, Two Pacific Place, 88 Queensway, Admiralty, Hong Kong FIL PENSION MANAGEMENT Oakhill House, 130 Tonbridge Road, Hildenborough, Kent, England TN119DZ JP MORGAN, BOURNEMOUTH (C) NATIONAL ASTL BK MELBOURNE (S) Investment Discretion/ Voting Power NORTHERN TRUST LONDON (C) BROWN BROS HARRIMN LTD LUX (C) CLEARSTREAM BANKING SA LUX (C) Investment Discretion/ Voting Power MASTER TRUST BANK OF JAPAN (C) NATIONAL ASTL BK MELBOURNE (S) Investment Discretion/ Voting Power Grand Total Nature of Relevent Interest Sum of Numerator Shares 201,323 433,673 207,114 21,790,870 493,135 814,708 1,734,285 25,675,108