Announcement PDF Form 604 Corporations Act 2001 Section 671B Notice of change of interests of substantial holder To Company Name/Scheme Starpharma Holdings Limited ACN/ARSN/ABN 078 532 180 1. Details of substantial holder (1) Name Allan Gray Australia Pty Ltd (Allan Gray Australia) and its related bodies corporate as set out in Table 1 of Annexure A (together the Group), as investment manager for the funds or investment mandates listed at Table 2 of Annexure A ACN/ARSN (if applicable) 112 316 168 (ACN of Allan Gray Australia) There was a change in the interests of the substantial holder on 8 September 2023 The previous notice was given to the company on 17 August 2023 The previous notice was dated 17 August 2023 2. Previous and present voting power The total number of votes attached to all the voting shares in the company or voting interests in the scheme that the substantial holder or an associate (2) had a relevant interest (3) in when last required, and when now required, to give a substantial holding notice to the company or scheme, are as follows: Previous notice Present notice Class of securities (4) Person's votes Voting power (5) Person's votes Voting power (5) Ordinary shares 51,965,719 12.66% 47,820,976 11.65% 3. Changes in relevant interests Particulars of each change in, or change in the nature of, a relevant interest of the substantial holder or an associate in voting securities of the company or scheme, since the substantial holder was last required to give a substantial holding notice to the company or scheme are as follows: Date of change Person whose relevant interest changed Nature of change (6) Consideration given in relation to change (7) Class and number of securities affected Person’s votes affected See Annexure A, Tables 2 and 3 4. Present relevant interests Particulars of each relevant interest of the substantial holder in voting securities after the change are as follows: Holder of relevant interest Registered holder of securities Person entitled to be registered as holder (8) Nature of relevant interest (6) Class and number of securities See Annexure A, Tables 2 and 4 5. Changes in association The persons who have become associates (2) of, ceased to be associates of, or have changed the nature of their association (9) with, the substantial holder in relation to voting interests in the company or scheme are as follows: Name and ACN/ARSN (if applicable) See Annexure A, Tables 1 and 2 Nature of association Person’s votes 6. Addresses The addresses of persons named in this form are as follows: Name Address The Group C/- Allan Gray Australia, Level 2 Challis House, 4 Martin Place Sydney , NSW 2000 Signature print name Elizabeth Lee sign here Company Secretary Date: 12 September 2023 DIRECTIONS (1) If there are a number of substantial holders with similar or related relevant interests (eg a corporation and its related corporations, or the manager and trustee of an equity trust), the names could be included in an annexure to the form. If the relevant interests of a group of persons are essentially similar, they may be referred to throughout the form as a specifically named group if the membership of each group, with the names and addresses of members is clearly set out in paragraph 6 of the form. (2) See the definition of “associate” in section 9 of the Corporations Act 2001. (3) See the definition of “relevant interest” in sections 608 and 671B(7) of the Corporations Act 2001. (4) The voting shares of a company constitute one class unless divided into separate classes. (5) The person’s votes divided by the total votes in the body corporate or scheme multiplied by 100. (6) Include details of: (a) any relevant agreement or other circumstances because of which the change in relevant interest occurred. If subsection 671B(4) applies, a copy of any document setting out the terms of any relevant agreement, and a statement by the person giving full and accurate details of any contract, scheme or arrangement, must accompany this form, together with a written statement certifying this contract, scheme or arrangement; and (b) any qualification of the power of a person to exercise, control the exercise of, or influence the exercise of, the voting powers or disposal of the securities to which the relevant interest relates (indicating clearly the particular securities to which the qualification applies). See the definition of “relevant agreement” in section 9 of the Corporations Act 2001. (7) Details of the consideration must include any and all benefits, money and other, that any person from whom a relevant interest was acquired has, or may, become entitled to receive in relation to that acquisition. Details must be included even if the benefit is conditional on the happening or not of a contingency. Details must be included of any benefit paid on behalf of the substantial holder or its associate in relation to the acquisitions, even if they are not paid directly to the person from whom the relevant interest was acquired. (8) If the substantial holder is unable to determine the identity of the person (eg if the relevant interest arises because of an option) write “unknown”. (9) Give details, if appropriate, of the present association and any change in that association since the last substantial holding notice. Starpharma Holdings Limited THIS IS ANNEXURE A OF 2 PAGES REFERRED TO IN THE ABOVE FORM 604 Print name Elizabeth Lee Company Secretary Sign here Date: 12 September 2023 Table 1 – Related bodies corporate The following entities are associates of Allan Gray Australia Pty Ltd (AGA) and each other by virtue of being related bodies corporate. Orbis Allan Gray Limited Orbis Mansfield Street Properties Ltd Orbis Holdings Limited Orbis Investment Management (BVI) Limited (OIMLBVI) Orbis Investment Management Limited (OIML) Orbis Investment Advisory Pty Limited Orbis Asset Management Limited (OAML) Allan Gray (Holdings) Pty Ltd Orbis Administration Limited Orbis Investment Management (Hong Kong) Limited Orbis Investment Research Limited Orbis Client Services (Canada) Limited Orbis Investment Management (MIS) Limited Orbis Holdings (UK) Limited Triple Blue Holdings Limited Orbis Investment Management (Europe) LLP Pictet Overseas Trust Corporation and Pictet Trustee Company SA Orbis Investment Management (Luxembourg) S.A Allan & Gill Gray Foundation (Guernsey) EmCap Limited (Guernsey) (EMCAP) Table 2 - Funds An entity within the Group acts as investment manager for some or all of the assets in the following funds. No 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. Fund name Allan Gray Australia Equity Fund Allan Gray Australia Balanced Fund Allan Gray Australia Stable Fund AMP Capital Specialist Australian Share Fund AMP Super Fund Future Directions Australian Equity Fund Morningstar Australian Shares High Alpha Fund Construction and Building Unions Superannuation Fund HESTA Superannuation Fund AustralianSuper Hostplus Pooled Superannuation Trust Russell Investments Australian Opportunities Fund Equipsuper Non-Government Schools Superannuation Fund REST Superannuation Fund Government Employees Superannuation Board Orbis Global Equity Fund (Australia Registered) Orbis Emerging Markets Equity Fund (Australia Registered) Orbis Global Equity LE Fund (Australia Registered) Orbis Global Balanced Fund (Australia Registered) Orbis Global Equity Fund Limited Orbis Optimal SA Fund Limited Institutional Global Equity Fund Orbis Optimal LP Orbis International Equity LP Orbis Institutional Global Equity LP Orbis Institutional International Equity LP Orbis Institutional U.S. Equity LP Orbis Institutional Emerging Markets Equity LP Orbis SICAV – Global Equity Fund Orbis SICAV – Emerging Markets Fund Orbis SICAV – Global Balanced Fund Orbis SICAV – International Equity Orbis OEIC Global Equity Fund Registered holder / Persons entitled to be registered holder Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch BNP Paribas Fund Services Australasia Pty Ltd BNP Paribas Fund Services Australasia Pty Ltd BNP Paribas Fund Services Australasia Pty Ltd JP Morgan Chase Bank JP Morgan Chase Bank JP Morgan Chase Bank JP Morgan Chase Bank Citibank N.A., Sydney Branch State Street Australia Ltd National Custodian Services State Street Australia Ltd State Street Australia Ltd Northern Trust Corporation Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch No 35. 36. 37. 38. Fund name Orbis Institutional Global Equity (OFO) OEIC Global Balanced Fund OEIC Global Cautious Fund Orbis SICAV Global Cautious Fund Registered holder / Persons entitled to be registered holder Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Citibank N.A., Sydney Branch Table 3 – Change in relevant interest Ordinary shares Person whose relevant interest Nature of Number of Date of change changed change securities Consideration 16 Aug 2023 to 8 Sep AGA and its associates listed in 2023 Table 1 Sells 4,144,743 611,510 All trades occur on market, via in-specie under a dividend reinvestment plan, or pursuant to a capital raising (as applicable). Currency AUD Table 4 – Present relevant interest Ordinary shares Holder of relevant interest AGA and its associates listed in Table 1 AGA and its associates listed in Table 1 AGA and its associates listed in Table 1 AGA and its associates listed in Table 1 AGA and its associates listed in Table 1 AGA and its associates listed in Table 1 Registered holder of securities / Person entitled to be registered as holder Number of securities held BNP Paribas Fund Services Australasia Pty Ltd 2,993,933 Citibank N.A., Sydney Branch 20,603,484 JP Morgan Chase Bank 9,927,742 National Custodian Services 4,232,372 Northern Trust Corporation 2,720,495 State Street Australia Ltd 7,342,950 Total 47,820,976 An entity within the Group acts as investment manager for the funds set out in Table 2 and the above registered holders hold all or some of the assets within those funds.