Jul 27, 2020

AZD0466 trial opens MD Anderson Cancer Center as a site

AZD0466 trial opens MD Anderson Cancer Center as a site

Melbourne, Australia; 27 July 2020: Starpharma (ASX: SPL, OTCQX: SPHRY) today announced the opening of the MD Anderson Cancer Center as a further trial site for the phase 1 trial of AZD0466, AstraZeneca’s first DEP® product.

AZD0466 is a highly optimised nanomedicine formulation of AstraZeneca’s novel dual Bcl2/xL inhibitor which utilises Starpharma’s DEP® technology. The development of AZD0466 is being progressed under a multi-product licence whereby Starpharma is eligible to receive development, launch and sales milestones.

Dr Jackie Fairley, Starpharma CEO, commented: “We’re pleased to see the ongoing progress of the AZD0466 trial. It is exciting to have this highly novel DEP®-based product being made available to patients at this leading international cancer center.”

About AZD0466

AZD0466 is a dendrimer-based formulation of a novel dual Bcl2/xL inhibitor developed under Starpharma’s multi-product DEP® licence with AstraZeneca. AZD0466 utilises DEP® to improve the formulation characteristics and therapeutic index of the anti-cancer agent and is currently in a phase 1 trial in the US. AZD0466 is described as having the potential to be a ‘best-in-class’ agent with a broad opportunity in solid and haematological tumours (blood cancers) due to its ability to target both Bcl2 and Bcl/xL. AZD0466 has demonstrated excellent anti-cancer activity in a wide range of preclinical tumour models including Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), Non-Hodgkin’s Lymphoma and Small Cell Lung Cancer (SCLC).

Download ASX Announcement: AZD0466 trial opens MD Anderson Cancer Center as a site (PDF, 52kb)

 This contains certain forward-looking statements.