Increasing Solubility

By joining the drug to a dendrimer construct, very large increases in drug solubility have been achieved, which can enhance the “bioavailability” of the drug. 

For example Docetaxel is a cancer drug well known for its poor aqueous solubility. When conjugated to a dendrimer construct a 20,000 fold increase in solublised Docetaxel is achieved.

The formulation of DEPTM docetaxel is also Polysorbate 80-free.

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DEPTM docetaxel (vial on right) 20,000 x increase in water solubility

 

Download DEP Drug Delivery Summary ( pdf file, 1007kb) or Contact Us for further information. 

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